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Mune varwere vane mild dilated cardiomyopathy (MDCM), kukwidziridzwa kwakanyanya kweC-reactive protein (hs-CRP) inosanganiswa nekuwedzera kwemazinga eN-terminal brain natriuretic peptide (NT-proBNP) kune varwere vane mild dilated cardiomyopathy (MDCM) .), kunyange zvazvo pasina humbowo hunotsigira chiitiko chekufungidzira chinosanganiswa nemigumisiro yevarwere.Mhedzisiro yacho yakaburitswa muESC Mwoyo Kutadza bhuku.
A retrospective analysis of varwere vane dilated cardiomyopathy (DCM) uye yakasara ventricular ejection chikamu pasi pe50% yakagamuchirwa kuFuwai Hospital muBeijing, China kubva munaDecember 2006 kusvika munaOctober 2017 yakaitwa.Vaongorori vakatsvaga kuenzanisa biomarkers NT-proBNP uye hs-CRP muvarwere veMDCM nevarwere veDCM.Muchidzidzo ichi, MDCM yakatsanangurwa seyakasara ventricular end-diastolic diameter index (LVEDDi) ye 33 mm / m2 kana pasi muvarume uye 34 mm / m2 muvakadzi.
Vakapinda muongororo iyi vanosvika mazana matanhatu nemakumi mana kubva muzana, zvikamu gumi nezvinomwe kubva muzana zvakanzi zvine MDCM uye 83% zvakanzi zvine DCM pakutanga.Pakazara, 24.8% yevatori vechikamu vaive vakadzi.Nguva yepakati yevarwere yaive makore 49.
Kuenzaniswa nevatori vechikamu veDCM, varwere veMDCM vakanga vari vaduku, vaiva nepamusoro-soro yeropa, chiitiko chepamusoro chechirwere cheshuga, chiyero chakaderera chetachycardia isingasviki ventricular, nhamba yepamusoro yemuviri, uye nguva pfupi yekugara muchipatara. Nezve cardiac biomarkers, varwere vane MDCM vaiva nechepamusoro-soro yepakati NT-proBNP mazinga akaenzana nevarwere vane DCM (2203 pg / mL vs 1448 pg / mL, maererano; P <.001). Nezve biomarkers, varwere vane MDCM vaiva nechepamusoro-soro yepakati NT-proBNP mazinga akaenzaniswa nevarwere vane mwoyo DCM (2203 pg / mL vs 1448 pg / mL, maererano; P <.001). Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнеентов в пациен 1/20 DCM; Maererano nemararamiro emwoyo, varwere veMDCM vakanga vane zvishoma zvishoma zvinoreva NT-proBNP mazinga akaenzaniswa nevarwere veDCM (2203 pg / mL vs. 1448 pg / mL, maererano; P <0.001).关于心脏生物标志物，与DCM 患者相比，MDCM 患者的NT-proBNP 水平中位数显着降低和（分20别1 pm/Pm4（分20别1 p.MDCM 患者的NT-proBNP 水平中位数显着降低（分别，与2203 pg/mL 和L0.0 pg/mL 和L0.0 Что касается сердечных биомаркеров, у пациентов с MDCM средний уровень NT-proBNP был значительно ниже по сравнечные биомаркеров, у пациентов с пациен 1/20 DCM, пациентов; Nezve cardiac biomarkers, zvinoreva NT-proBNP mazinga aive akaderera zvakanyanya muvarwere veMDCM vachienzaniswa nevarwere veDCM (2203 pg/mL uye 1448 pg/mL, zvichiteerana; P <0.001).Kusiyana neizvi, zvinoreva hs-CRP mazinga akanga akakwirira muvarwere veMDCM kupfuura muvarwere veDCM (3.09 mg / L uye 2.79 mg / L, maererano; P = 0.39).
Pakati pevarwere ve282 avo vakawana echocardiographic kutevera mukati memwedzi mitanhatu kana kupfuura, varwere vanomwe vane MDCM (11.1%) vakagadzira DCM, nepo varwere makumi manomwe vane DCM (32.0%) vakadzokera kuMDCM, sezvakaita shanduko muLVEDDi yakaonekwa.
Baseline MDCM varwere vaiva nengozi yakaderera yakasanganiswa yezvose-zvinokonzera kufa, kuisirwa mwoyo, uye kuverenga kwekukundikana kwemoyo zvichienzaniswa nevatori vechikamu DCM (yakagadziriswa hazard ratio [aHR], 0.63; 95% CI, 0.43-0.93; P = 0.019).
Ose ari maviri hs-CRP uye NT-proBNP mazinga akazvimiririra akabatana neyakasanganiswa yekupedzisira pane yese yekudzidza cohort (hs-CRP, aHR, 1.07; 95% CI, 1.00-1.15 uye NT-proBNP: aHR , 1.11, 95% CI, 1.02–1.22, p = 0.019).
Mushure mekuenzanisa maitiro ehutano pakati peMDCM neDCM, kushamwaridzana pakati pemazinga epamusoro eNT-proBNP uye kuguma kwakabatanidzwa kwakaenderana nezvakataurwa vasati vaenzanisa varwere vane DCM (RR, 1.83; 95% CI, 1.05-3.20; P = 0.034), asi kwete muvarwere vane MDCM (HR, 1.54, 95% CI, 0.76-3.11, P = 0.227).Kusiyana neizvi, hs-CRP mazinga akanga achiri kunyanya kubatanidzwa nekufungidzira kune varwere vane MDCM (RR 3.19; 95% CI 1.52-6.66; P = 0.002), asi kwete kune varwere vane DCM (RR 1.04; 95% CI).0.61–1.79;p = 0.88).
Mhedzisiro yekudzidza ndeyokuti phenotype yevarwere inogona kuchinja panguva yekutevera, kunyange zvazvo nhamba yevanhu vakadzokorora echocardiography yakanga iri duku, saka kufungidzira kwekuchinja kwe phenotypic hakuna kuongororwa.Mukuwedzera, nekuda kwehukuru hukuru hwemuenzaniso wevarwere veMDCM muchidzidzo, zvinogona kuvhiringidza zvinhu hazvina kunyatsogadziriswa muhuwandu hwekuongorora.
"Baseline hs-CRP yakabatanidzwa nemigumisiro yakabatanidzwa muvarwere veMDCM vasati uye mushure mekugadzirisa kune covariates, nepo NT-proBNP yaingobatanidzwa nemigumisiro muDCM," vanyori vekudzidza vanocherechedza."Zvimwe zvidzidzo zvinodiwa kuti uongorore kufanotaura kwekuchinja kwe ventricular geometry uye cardiac function, kunyanya kune varwere vane MDCM, kupa hutano hwakanyanya hwengozi."
kuburitsa: Hapana wevanyori vezvidzidzo vakati vanobatana nebiotech, mishonga, uye/kana makambani emidziyo.
Feng J, Tian P, Liang L, nevamwe.Mhedzisiro uye kukosha kweprognostic yeN-terminal pro-brain natriuretic peptide uye yakakwirira-sensitivity C-reactive protein mune mild and dilated cardiomyopathies.ESC mwoyo kukundikana.Rakadhindwa pamhepo Kurume 4, 2022 doi: 10.1002/ehf2.13864
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