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Chiyero chekukurumidza cheBNP kuona kana murwere ari kuuya nekupfupika kwekufema angave ari kutambura ne congestive heart failure.

BNP yakavanzwa ne cardiomyocytes uye inogona kudzivisa kupararira kwevascular smooth muscle masero uye fibroblasts, ichiita basa rinokosha mukugadzirisa vascular uye kugadzirisa kweropa.Muchiitiko che hypervolemia kana mamwe mamiriro anokonzera ventricular kutambanudza, muviri unogadzira BNP uye unoiisa muropa kudzora kuenzana kwemvura yemuviri uye electrolyte kuburikidza nekubatana ne renin angiotensin aldosterone system (RAAS).Muzvirwere zvemoyo senge congestive heart failure, hypertension, acute myocardial infarction, myocardial hypertrophy uye cardiomyopathy, B-type brain natriuretic peptide gene expression, synthesis uye secretion inowedzera zvakanyanya.Naizvozvo, uropi natriuretic peptide inogona kushandiswa mukubatsira kuongororwa kwekutadza kwemoyo.